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Molecular profiling of the developing mouse axial skeleton: a role for Tgfbr2 in the development of the intervertebral disc

Conclusions: We propose TGF-b has two functions in IVD development: 1) to prevent chondrocyte differentiation in the presumptive IVD and 2) to promote differentiation of annulus fibrosus from sclerotome. We have identified genes that are enriched in the IVD and regulated by TGF-b that warrant further investigation as regulators of IVD development. (Source: BMC Developmental Biology - Latest articles) (original story)


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